Mechanism of antiplatelet action by natural products on PPARs. cAMP = cyclic adenosine monophosphate; PKA = protein kinase A; TXA2 = thromboxane A2; PKC = protein kinase C; PLC = phospholipase; COX-1 = cyclooxygenase-1; PPARs = peroxisome proliferator-activated receptors; AKT = also known as protein kinase B; NO = nitric oxide; cGMP = cyclic guanosine monophosphate; PKG = protein kinase G; NOS = nitric oxide synthase.