The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction

Table 1

Effect of C4 against promastigote and axenic amastigote forms of Leishmania amazonensis, cytotoxicity in macrophages cells, and selectivity index.

Cells	C4 (µM) IC50^a	C4 (µM) IC90^b	SI^c
Promastigotes	16.0±2.28	103.0±20.17	45.1
Axenic amastigotes	16.3±2.38	118.0±45	44.2
Macrophages (CC50)^d	722.0±45	—	—

aConcentration that inhibited 50% of growth.
bConcentration that inhibited 90% of growth.
cSelectivity index (SI; CC₅₀ macrophages/IC₅₀).
d50% cytotoxicity concentration in macrophages.