Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice
Figure 9
Influence of BV on the antitumor effect of cisplatin. All mice received injections of EL4 lymphoma cells ( mL) s.c. into the right flank. BV (1 mg/kg) was injected once per day for 5 days from day 5 of tumor inoculation (). Cisplatin was injected 3 times (on days 11, 14, and 17) at a concentration of 5 mg/kg. All mice were sacrificed at day 20, and the tumors were photographed (a). The tumor size was measured every three days after BV injection for 16 days. After sacrifice, the tumors were fully separated from the mice, and the size (b) and weight (c) of the tumors were measured. All data are presented as the mean ± SEM. versus cont; NS, versus Cis, as determined by one-way ANOVA followed by Tukey’s test.
