- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 879845, 10 pages
http://dx.doi.org/10.1155/2013/879845
Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice
1Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
2Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea
3Institute of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
Received 27 August 2012; Revised 17 December 2012; Accepted 26 December 2012
Academic Editor: Bashar Saad
Copyright © 2013 Hyunseong Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- K. B. Meyer and N. E. Madias, “Cisplatin nephrotoxicity,” Mineral and Electrolyte Metabolism, vol. 20, no. 4, pp. 201–213, 1994. View at Scopus
- A. H. Lau, “Apoptosis induced by cisplatin nephrotoxic injury,” Kidney International, vol. 56, no. 4, pp. 1295–1298, 1999. View at Publisher · View at Google Scholar · View at Scopus
- R. Safirstein, J. Winston, M. Goldstein, et al., “Cisplatin nephrotoxicity,” American Journal of Kidney Diseases, vol. 8, no. 5, pp. 356–367, 1986. View at Scopus
- J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, “Foxp3 programs the development and function of CD4+CD25+ regulatory T cells,” Nature Immunology, vol. 4, no. 4, pp. 330–336, 2003. View at Publisher · View at Google Scholar · View at Scopus
- G. Raimondi, M. S. Turner, A. W. Thomson, and P. A. Morel, “Naturally occurring regulatory T cells: recent insights in health and disease,” Critical Reviews in Immunology, vol. 27, no. 1, pp. 61–95, 2007. View at Scopus
- S. Sakaguchi, M. Ono, R. Setoguchi et al., “Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease,” Immunological Reviews, vol. 212, no. 1, pp. 8–27, 2006. View at Publisher · View at Google Scholar · View at Scopus
- S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, “Immunologic self-tolerance maintained by activated T cells expressing IL- 2 receptor α-chains (CD25). Breakdown of a single mechanism of self- tolerance causes various autoimmune diseases,” Journal of Immunology, vol. 155, no. 3, pp. 1151–1164, 1995. View at Scopus
- H. Lee, D. Nho, H. S. Chung et al., “CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice,” Kidney International, vol. 78, no. 11, pp. 1100–1109, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. H. Park, M. S. Choi, D. H. Kwak et al., “Anti-cancer effect of bee venomin prostate cancer cells through activation of caspase pathway via inactivation of NF-κB,” Prostate, vol. 71, no. 8, pp. 801–812, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Y. Yoon, Y. B. Kwon, H. W. Kim et al., “Bee venom injection produces a peripheral anti-inflammatory effect by activation of a nitric oxide-dependent spinocoeruleus pathway,” Neuroscience Letters, vol. 430, no. 2, pp. 163–168, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. B. Kwon, H. W. Kim, T. W. Ham et al., “The anti-inflammatory effect of bee venom stimulation in a mouse air pouch model is mediated by adrenal medullary activity,” Journal of Neuroendocrinology, vol. 15, no. 1, pp. 93–96, 2003. View at Publisher · View at Google Scholar · View at Scopus
- H. Lee, E. J. Lee, H. Kim et al., “Bee venom-associated Th1/Th2 immunoglobulin class switching results in immune tolerance of NZB/W F1 murine lupus nephritis,” American Journal of Nephrology, vol. 34, no. 2, pp. 163–172, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. Megyesi, R. L. Safirstein, and P. M. Price, “Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure,” The Journal of Clinical Investigation, vol. 101, no. 4, pp. 777–782, 1998. View at Publisher · View at Google Scholar
- K. K. Meldrum, P. Metcalfe, J. A. Leslie, R. Misseri, K. L. Hile, and D. R. Meldrum, “TNF-α neutralization decreases nuclear factor-κB activation and apoptosis during renal obstruction,” Journal of Surgical Research, vol. 131, no. 2, pp. 182–188, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Linkermann, N. Himmerkus, L. Rölver et al., “Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure,” Kidney International, vol. 79, no. 2, pp. 169–178, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T. Muthukumar, D. Dadhania, R. Ding et al., “Messenger RNA for FOXP3 in the urine of renal-allograft recipients,” The New England Journal of Medicine, vol. 353, no. 22, pp. 2342–2351, 2005. View at Publisher · View at Google Scholar · View at Scopus
- G. R. Kinsey, R. Sharma, L. Huang et al., “Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury,” Journal of the American Society of Nephrology, vol. 20, no. 8, pp. 1744–1753, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Bunnag, K. Allanach, G. S. Jhangri et al., “FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes,” American Journal of Transplantation, vol. 8, no. 7, pp. 1423–1433, 2008. View at Publisher · View at Google Scholar · View at Scopus
- H. Kim, G. Lee, H. Lee, M. Shin, M. Hong, and H. Bae, “Effects of Scutellaria barbata on cisplatin induced nephrotoxicity in mice,” Molecular and Cellular Toxicology, vol. 6, no. 3, pp. 255–259, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. Wang, Q. Cai, G. Zheng, et al., “By homing to the kidney, activated macrophages potently exacerbate renal injury,” The American Journal of Pathology, vol. 172, no. 6, pp. 1491–1499, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Faubel, E. C. Lewis, L. Reznikov et al., “Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1β, IL-18, IL-6, and neutrophil infiltration in the kidney,” Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 1, pp. 8–15, 2007. View at Publisher · View at Google Scholar · View at Scopus
- G. Ramesh and W. Brian Reeves, “TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity,” The Journal of Clinical Investigation, vol. 110, no. 6, pp. 835–842, 2002. View at Publisher · View at Google Scholar · View at Scopus
- F. Ries and J. Klastersky, “Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity,” American Journal of Kidney Diseases, vol. 8, no. 5, pp. 368–379, 1986. View at Scopus
- N. Oršol, “Bee venom in cancer therapy,” Cancer and Metastasis Reviews, vol. 31, no. 1-2, pp. 173–194, 2012. View at Publisher · View at Google Scholar
- N. Oršolić, L. Šver, S. Verstovšek, S. Terzić, and I. Bašić, “Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom,” Toxicon, vol. 41, no. 7, pp. 861–870, 2003.