Table 4: Identification of differentially expressed metabolites in the plasma that may account for the discrimination between normal and model rats.

No.MetabolitesFormula Obsd. [M + H]+/[M − H] ( )Content variancecFCd e value

1LysoPC (22:5 (7Z, 10Z, 13Z, 16Z, 19Z)) 568.3436a−2.330.018
25-Dehydro-4-deoxy-D-glucarateC6H8O7191.0197a2.560.022
3LysoPC (17:0)C25H52NO7P508.3403a−1.420.030
45α-TetrahydrocorticosteroneC21H34O4349.2378a2.560.035
5PC (13:0/0:0)C21H44NO7P452.2774a1.250.021
617-phenyl trinor PGF2α methyl esterC24H34O5404.2438b2.010.017
7PC (0:0/18:0)C26H54NO7P524.3720b−1.350.042
8LysoPC (18:2 (9Z, 12Z))C26H50NO7P520.3424b−1.560.030
9LysoPC (16:0)C24H50NO7P496.3450b−1.780.016
10LysoPC (22:6 (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)) 568.3421b−2.600.026

Observed at ES mode [M − H]; bobserved at ES+ mode [M + H]+.
: content increased; : content decreased.
dFold change was calculated as the ratio of the mean metabolite levels between two groups. A positive value of fold change indicates a relatively higher concentration of metabolites, while a negative value of fold change indicates a relatively lower concentration of metabolites in model rats as compared to normal rats.
e values were calculated from two-tailed Mann-Whitney test with a threshold of 0.05.