The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by D-Galactosamine in Rats

Figure 4

The mRNA expression. (a) HMGB1; (b) TLR4; (c) NF-κB; (d) Caspase-3. Control: negative control group; Model: the group injected with D-GalN; SNMC: the group injected with D-GalN and treated with Stronger Neo-Minophagen C; Experiment: the group injected with D-GalN and treated with Qinggan Huoxue Recipe. For Control, Model, SNMC, and Experiment groups, the HMGB1 mRNA expressions were 0.01±0.01, 0.25±0.04, 0.11±0.04, and 0.07±0.06, respectively; the TLR4 mRNA expressions were 0.04±0.02, 0.41±0.22, 0.22±0.08, and 0.08±0.04, respectively; the NF-κB mRNA expressions were 0.49±0.25, 2.68±1.35, 1.78±0.64, and 0.98±0.63, respectively; and the Caspase-3 mRNA expressions were 1.36±0.26, 3.41±0.85, 2.57±1.04, and 1.64±0.81, respectively. ^&𝑃<0.05 comparing Control group, ^#𝑃<0.05 comparing Model group, and ^▴𝑃<0.05 comparing SNMC group.

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