Bioactive Fraction of Geopropolis from Melipona scutellaris Decreases Neutrophils Migration in the Inflammatory Process: Involvement of Nitric Oxide Pathway
Table 2
Aqueous fraction effect on carrageenan-induced paw edema on mice.
Treatment (mg/kg)
Time (h) after injection of carrageenan
1
2
3
4
5
Carrageenan
0.08 ± 0.01
0.10 ± 0.02
0.13 ± 0.01
0.16 ± 0.02
0.15 ± 0.01
Aqueous fraction 1 mg/kg
0.10 ± 0.01
0.11 ± 0.01
0.11 ± 0.01
0.14 ± 0.01
0.13 ± 0.01
Aqueous fraction 3 mg/kg
0.08 ± 0.01
0.09 ± 0.02
0.09 ± 0.01
0.13 ± 0.01
0.13 ± 0.01
Aqueous fraction 10 mg/kg
0.06 ± 0.01
0.08 ± 0.01
0.08 ± 0.02
0.11 ± 0.02
0.11 ± 0.01
Aqueous fraction 30 mg/kg
0.06 ± 0.01
0.05 ± 0.02
0.06 ± 0.02*
0.08 ± 0.03*
0.09 ± 0.02
The data are expressed as mean ± SEM, n = 6. Symbols indicate statistical difference (P < 0.05, Tukey test). *Compared to the carrageenan group.
