Cucurbitane Triterpenoid from <i>Momordica charantia</i> Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor <i>γ</i> Activation

<table>Effects of DMC on the activation status of the Akt-mTOR signaling axis and AMPK. (a) Dose-dependent of DMC on the phosphorylation/expression of Akt, mTOR, p70S6K, and HIF1<i>α</i> in MCF-7 cells after 72 h exposure in 5% FBS-DMEM/F12 (left panel). Effects of 15 <i>μ</i>M DMC, 15 <i>μ</i>M troglitazone, or 5 <i>μ</i>M GW9662 or the drug combination relative to DMSO control in MCF-7 cells after 72 h exposure in 5% FBS-DMEM/F12 (right panel). (b) Dose-dependent effects of DMC on the phosphorylation of AMPK and ACC in MCF-7 (left panel) and MDA-MB-231 (right panel) cells after 72 h exposure in 5% FBS-DMEM/F12.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: Cucurbitane Triterpenoid from <i>Momordica charantia</i> Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor <i>γ</i> Activation 

Figure 5 | Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation 