A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

Table 2

Active compounds of blood-tonifying herbs in this work and their targets of different diseases.

Disease	TCM	Molecular	Target	Reference*
Regulate hemopoietic growth factor	Radix paeoniae alba	Albiflorin	PKC𝛼
	Radix paeoniae alba	Paeonioflorin	IL-6, LBP, PKC𝛼, TNF
	Angelica sinensis	Ferulic acid	ADRA2A, PTGER4, SHP-2, F2, TUBB1
	Angelica sinensis	ligustilide	SOD1, TNF^a
	Polygonum multiflorum	Stilbene glucoside	CALM, F7, F10, F2, NQO2, PTPN1
	Rehmannia glutinosa	Catalpol	NOS2^b, F2, SOD1
	Rehmannia glutinosa	Verbascoside	PKC𝛼, F2
Regulate bone marrow stromal cell	Radix paeoniae alba	Paeonioflorin	CD14
	Angelica sinensis	Ferulic acid	MAOA, MAOB, DPP-IV, ITGB3, ITGB5, MAOB, ITGAV	[15]
	Angelica sinensis	ligustilide	ACHE^b
	Polygonum multiflorum	Stilbene glucoside	DPP-IV
	Rehmannia glutinosa	Catalpol	DPP-IV
	Rehmannia glutinosa	Verbascoside	CAM1
Regulate hematopoietic stem cell apoptosis	Angelica sinensis	Ferulic acid	APP, ADRB2, CDK2, DNA pol beta, MIF, PTGER2, PTGER3, RARG, PIM1, TBXAS1
	Angelica sinensis	ligustilide	BAX^b, Bcl-2, CASP3^b
	Polygonum multiflorum	Stilbene glucoside	CDK2, CCNA2, PIM1
	Rehmannia glutinosa	5-Hydroxymethyl-furoic acid	CDK2	[17]
	Rehmannia glutinosa	Catalpol	Bcl-2^c, CASP3^b
	Rehmannia glutinosa	Verbascoside	APP

∗The corresponding efficacy of botanic drug has been supported by the literature.
Superscript with targets: The functional activity of the components with regard to the targets.
^aDown-regulate gene. ^bDecrease expression or activity. ^cIncrease expression level or activity. ^dDirectly inhibit.