Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids from Illicium difengpi and Their Anti-Inflammatory Activities

Table 2

Screening anti-inflammation targets over molecule docking of compounds 1–5.

Compound number	Molecules docking results
	Target name	Fit score	Norm fit score
	Dual specificity mitogen-activated protein kinase kinase 1 (MPKK1)	4.111	0.4567
	Glucocorticoid receptor (GR)	4.010	0.5012
	Prothrombin	3.843	0.4271
1/2	Alpha-1-antitrypsin	3.834	0.6390
	Glycogen synthase kinase-3 beta	3.786	0.5409
	ADAM 17	3.726	0.9315
	Tyrosine-protein kinase SYK	3.712	0.6187
	Protein kinase C theta type	3.701	0.5287
	Dual specificity mitogen-activated protein kinase kinase 1 (MPKK1)	5.171	0.5745
	Proto-oncogene tyrosine-protein kinase LCK	4.370	0.4370
3	Glucocorticoid receptor	4.332	0.5415
	Glycogen synthase kinase-3 beta	4.298	0.6140
	Cathepsin B	4.110	0.4566
	Peroxisome proliferator-activated receptor alpha	4.042	0.5053
	Prothrombin	3.988	0.6646
	Dual specificity mitogen-activated protein kinase kinase 1 (MPKK1)	3.660	0.4067
4	Proto-oncogene tyrosine-protein kinase LCK	3.596	0.5137
	Prothrombin	3.496	0.3885
	Leukotriene A-4 hydrolase	3.354	0.3727
	Dual specificity mitogen-activated protein kinase kinase 1 (MPKK1)	4.246	0.4718
	Glucocorticoid receptor	3.931	0.4913
	Estrogen receptor	3.728	0.5325
	Leukocyte elastase	3.709	0.4121
5	Protein kinase C theta type	3.689	0.5270
	Glycogen synthase kinase-3 beta	3.642	0.5203
	Proto-oncogene tyrosine-protein kinase LCK	3.626	0.6044
	Mitogen-activated protein kinase 10	3.596	0.5137
	Peroxisome proliferator-activated receptor alpha	3.576	0.4470