Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B: A Dynamical Network Analysis of miRNA Array Data

Table 4

BIOCART terms distribution of downregulated genes (upexpression level of miRNAs) of TCM syndromes in CHB.

Syndromes	Biocart term	Genes
LGDHS/normal	Hypoxia-inducible factor in the cardiovascular system	EP300, VHL, CREB1, VEGFA, ASPH
LDSDS/normal	Control of gene expression by vitamin D receptor	COPS2, BAZ1B, SMARCC1, SMARCD1, CHAF1A, SMARCA4
LKYDS/normal	Melanocyte development and pigmentation pathway	CREB1, BCL2, MITF, KITLG, KIT
LGDHS/LDSDS	Cell cycle: G1/S checkpoint	E2F1, SMAD4, SKP2, CDK6, RB1, CDK4, ATM, CDC25A, CCND1, CDKN1A, CDKN1B, DHFR, CDKN2A, HDAC1, CDKN2B
	p53 signaling pathway	E2F1, CDKN1A, CCND1, BCL2, PCNA, APAF1, RB1, CDK4, TIMP3, GADD45A, ATM
	Cyclin, cell cycle regulation	E2F1, CCNB1, CDKN1A, CCND1, CDKN1B, CDKN2A, CDKN2B, CDK6, RB1, CDK4, CDC25A
	Cell cycle: G2/M checkpoint	CCNB1, CDKN1A, YWHAH, EP300, CHEK1, MYT1, GADD45A, ATM, BRCA1, WEE1
LDSDS/LKYDS	Role of BRCA1, BRCA2, and ATR in cancer susceptibility	RAD1, NBN, BRCA2, BRCA1, RAD51
	Cyclin, cell cycle regulation	CCNE1, CDKN2A, CDKN2D, RB1, CDC25A