Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B: A Dynamical Network Analysis of miRNA Array Data

Table 5

BIOCART terms distribution of upregulated genes (downexpression level of miRNAs) of TCM syndromes in CHB.

Category	Term	Genes
LGDHS/normal	Prion pathway	RPSA, BCL2, LAMC1, DNAJB1, HSPA5, LAMB1, PRNP
LDSDS/normal	Signaling pathway from G-protein families	RPS6KA3, GNAQ, MAP2K1, GNB1, JUN, PPP3CA
LKYDS/normal	ALK in cardiac myocytes	TGFBR1, SMAD5, TGFBR2, SMAD4, BMPR2, BMP7, ATF2, BMPR1A, ACVR1, APC
	Melanocyte development and pigmentation pathway	CREB1, BCL2, MITF, KITLG, KIT
LGDHS/LDSDS	No	No
LDSDS/LKYDS	Cell cycle: G1/S check point	E2F1, SMAD4, SMAD3, CDK6, RB1, CDK4, ATM, CDC25A, CCND1, CDKN1A, CDKN1B, DHFR, CDKN2A, HDAC1, CDKN2B, CCNA1
	p53 signaling pathway	E2F1, CDKN1A, CCND1, BCL2, BAX, PCNA, APAF1, RB1, CDK4, TIMP3, ATM