Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

Figure 2

Effects of SYD postconditioning on ischemia-reperfusion (I/R) injury in the sham, I/R, IPoC, low-dose (L)-SYD (3 g/kg/day), and high-dose (H)-SYD (6 g/kg/day) groups. (a) serum LDH activity; (b) serum CK-MB activity; (c) Serum MDA content; and (d) serum SOD activity. Data are expressed as mean ± SD (𝑛=8). ^#𝑃<0.05 versus sham; *𝑃<0.05 versus I/R. (e) Representative images of H&E-stained sections. In the I/R group, myocardial fiber loss and disruption are evident, and this is reversed by SYD treatment. SYD (both L- and H-dose) was administered via duodenal injection. Scale bar represents 50 μm.

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