Zuo Jin Wan, a Traditional Chinese Herbal Formula, Reverses P-gp-Mediated MDR In Vitro and In Vivo

Figure 2

Effect of ZJW on the sensitivity to chemotherapeutic drug in human cancer cells. (a) The cells were treated with various concentrations of ZJW and analysis by CCK-8 analyses. (b) Antiproliferative IC₅₀ values of L-OHP, DDP, and 5-Fu on HCT116/L-OHP, SGC7901/DDP, and Bel/Fu cells were analyzed by CCK-8 analyses. Data are presented as mean ± SD of triplicate experiments. ^∗𝑃<0.05,^∗∗𝑃<0.01,^#𝑃<0.05, and ^##𝑃<0.01 versus control. (c) CCK-8 assay was used to detect cell inhibition of L-OHP, DDP, 5-Fu, and MMC in HCT116/L-OHP cells treated with ZJW at 50 μg/mL for 48 h.

(a)

(b)

(c)