Zuo Jin Wan, a Traditional Chinese Herbal Formula, Reverses P-gp-Mediated MDR In Vitro and In Vivo
Figure 6
Inhibition effect of ZJW in vivo. (a) Tumor volume change was determined every two days during delivery period. Values are mean weight of nude mice ± SD. Statistical difference was analyzed by Student’s -test. represents that L-OHP (5 mg/kg) treatment group is significantly different from control group; represents that L-ZJW (1027.5 mg/kg) + L-OHP (5 mg/kg) treatment group is significantly different from control group; represents that M-ZJW(2055 mg/kg) + L-OHP (5 mg/kg) treatment group is significantly different from control group; represents that H-ZJW(4110 mg/kg) + L-OHP (5 mg/kg) treatment group is significantly different from control group. (b) Tumors removed from nude mice and photographed on the 28th day after administration. (c) Overall survival of xenograft model after injection with HCT116/L-OHP cells.
