Journal Menu
- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 958025, 11 pages
http://dx.doi.org/10.1155/2013/958025
Research Article
Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs
Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan
Received 23 August 2012; Revised 15 November 2012; Accepted 15 November 2012
Academic Editor: Andreas Sandner-Kiesling
Copyright © 2013 Chieh-Fang Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- A. Jemal, R. Siegel, J. Xu, and E. Ward, “Cancer statistics, 2010,” CA: A Cancer Journal for Clinicians, vol. 60, pp. 277–300, 2010.
- J. M. Llovet, S. Ricci, V. Mazzaferro et al., “Sorafenib in advanced hepatocellular carcinoma,” The New England Journal of Medicine, vol. 359, no. 4, pp. 378–390, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. Numata, A. Yamamoto, A. Moribayashi, and H. Yamada, “Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi,” Planta Medica, vol. 60, no. 4, pp. 356–359, 1994. View at Publisher · View at Google Scholar · View at Scopus
- M. Su, H. Y. Chung, and Y. Li, “6-O-Angeloylenolin induced cell-cycle arrest and apoptosis in human nasopharyngeal cancer cells,” Chemico-Biological Interactions, vol. 189, pp. 167–176, 2011. View at Publisher · View at Google Scholar
- H. Ohba, S. Moriwaki, R. Bakalova, S. Yasuda, and N. Yamasaki, “Plant-derived abrin-a induces apoptosis in cultured leukemic cell lines by different mechanisms,” Toxicology and Applied Pharmacology, vol. 195, pp. 182–193, 2004. View at Publisher · View at Google Scholar
- R. V. Priyadarsini, R. S. Murugan, P. Sripriya, D. Karunagaran, and S. Nagini, “The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells,” Free Radical Research, vol. 44, no. 6, pp. 624–634, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Zhao, B. Shan, Y. Du, M. Wang, L. Liu, and F. Z. Ren, “Periplocin from Cortex periplocae inhibits cell growth and down-regulates survivin and c-myc expression in colon cancer in vitro and in vivo via β-catenin/TCF signaling,” Oncology Reports, vol. 24, no. 2, pp. 375–383, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Z. J. Lu, Y. Zhou, Q. Song et al., “Periplocin inhibits growth of lung cancer in vitro and in vivo by blocking AKT/ERK signaling pathways,” Cellular Physiology and Biochemistry, vol. 26, pp. 609–618, 2010. View at Publisher · View at Google Scholar
- S. R. Wiley, K. Schooley, P. J. Smolak et al., “Identification and characterization of a new member of the TNF family that induces apoptosis,” Immunity, vol. 3, no. 6, pp. 673–682, 1995. View at Publisher · View at Google Scholar · View at Scopus
- G. Pan, K. O'Rourke, A. M. Chinnaiyan et al., “The receptor for the cytotoxic ligand TRAIL,” Science, vol. 276, no. 5309, pp. 111–113, 1997. View at Publisher · View at Google Scholar · View at Scopus
- P. M. Chaudhary, M. Eby, A. Jasmin, A. Bookwalter, J. M. Urray, and L. Hood, “Death receptor 5, a new member of the TNFR family, and DR4 induce FADD- dependent apoptosis and activate the NF-κB pathway,” Immunity, vol. 7, no. 6, pp. 821–830, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Smyth, K. Takeda, Y. Hayakawa, J. J. Peschon, M. R. van den Brink, and H. Yagita, “Nature's TRAIL—on a path to cancer immunotherapy,” Immunity, vol. 18, pp. 1–6, 2003. View at Publisher · View at Google Scholar
- E. Cretney, A. Shanker, H. Yagita, M. J. Smyth, and T. J. Sayers, “TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer,” Immunology & Cell Biology, vol. 84, pp. 87–98, 2006. View at Publisher · View at Google Scholar
- C. M. M. Van Geelen, E. G. E. De Vries, and S. De Jong, “Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy,” Drug Resistance Updates, vol. 7, no. 6, pp. 345–358, 2004. View at Publisher · View at Google Scholar · View at Scopus
- Y. Zhang and B. Zhang, “TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5,” Molecular Cancer Research, vol. 6, pp. 1861–1871, 2008. View at Publisher · View at Google Scholar
- K. Chen, Y. Tu, Y. Zhang, H. C. Blair, L. Zhang, and C. Wu, “PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells,” The Journal of Biological Chemistry, vol. 283, pp. 2508–2517, 2008.
- S. Khanbolooki, S. T. Nawrocki, T. Arumugam et al., “Nuclear factor-κB maintains TRAIL resistance in human pancreatic cancer cells,” Molecular Cancer Therapeutics, vol. 5, no. 9, pp. 2251–2260, 2006. View at Publisher · View at Google Scholar · View at Scopus
- L. Zhang, H. Zhu, J. J. Davis et al., “Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death,” Cancer Biology and Therapy, vol. 3, no. 3, pp. 296–301, 2004. View at Scopus
- R. R. Rosato, J. A. Almenara, S. Coe, and S. Grant, “The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation,” Cancer Research, vol. 67, no. 19, pp. 9490–9500, 2007. View at Publisher · View at Google Scholar · View at Scopus
- J. F. Yang, J. G. Cao, L. Tian, and F. Liu, “5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells,” Cancer Chemotherapy and Pharmacology, vol. 69, pp. 195–206, 2012. View at Publisher · View at Google Scholar
- C. H. Ko, S. C. Shen, and Y. C. Chen, “Hydroxylation at C4′ or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species,” Free Radical Biology and Medicine, vol. 36, no. 7, pp. 897–910, 2004. View at Publisher · View at Google Scholar · View at Scopus
- O. Pellerito, G. Calvaruso, P. Portanova et al., “The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis,” Molecular Pharmacology, vol. 77, no. 5, pp. 854–863, 2010. View at Publisher · View at Google Scholar · View at Scopus
- W. Ding, T. Cai, H. Zhu et al., “Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo,” Cancer Letters, vol. 293, pp. 158–166, 2010. View at Publisher · View at Google Scholar
- Y. Hayakawa, V. Screpanti, H. Yagita et al., “NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy,” Journal of Immunology, vol. 172, no. 1, pp. 123–129, 2004. View at Scopus
- M. J. Smyth, E. Cretney, K. Takeda et al., “Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon γ-dependent natural killer cell protection from tumor metastasis,” Journal of Experimental Medicine, vol. 193, no. 6, pp. 661–670, 2001. View at Publisher · View at Google Scholar · View at Scopus
- H. Zhang, D. Z. Qian, Y. S. Tan et al., “Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 50, pp. 19579–19586, 2008. View at Publisher · View at Google Scholar · View at Scopus
- B. Stenkvist, “Is digitalis a therapy for breast carcinoma?” Oncology Reports, vol. 6, pp. 493–496, 1999.
- B. Stenkvist, E. Pengtsson, B. Dahlqvist, O. Eriksson, T. Jarkrans, and B. Nordin, “Cardiac glycosides and breast cancer, revisited,” The New England Journal of Medicine, vol. 306, no. 8, article 484, 1982.
- F. Qi, Y. Inagaki, B. Gao et al., “Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways,” Cancer Science, vol. 102, no. 5, pp. 951–958, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Lin, J. L. Juang, and P. S. Wang, “Involvement of Cdk5/p25 in digoxin-triggered prostate-cancer cell apoptosis,” Journal of Biological Chemistry, vol. 279, no. 28, pp. 29302–29307, 2004. View at Publisher · View at Google Scholar · View at Scopus
- M. Ramirez-Ortega, G. Zarco, V. Maldonado et al., “Is digitalis compound-induced cardiotoxicity, mediated through guinea-pig cardiomyocytes apoptosis?” European Journal of Pharmacology, vol. 566, no. 1–3, pp. 34–42, 2007. View at Publisher · View at Google Scholar · View at Scopus
- A. Suliman, A. Lam, R. Datta, and R. K. Srivastava, “Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways,” Oncogene, vol. 20, no. 17, pp. 2122–2133, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. A. Degli-Esposti, P. J. Smolak, H. Walczak et al., “Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family,” Journal of Experimental Medicine, vol. 186, no. 7, pp. 1165–1170, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. A. Degli-Esposti, W. C. Dougall, P. J. Smolak, J. Y. Waugh, C. A. Smith, and R. G. Goodwin, “The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL- mediated apoptosis, yet retains an incomplete death domain,” Immunity, vol. 7, no. 6, pp. 813–820, 1997. View at Publisher · View at Google Scholar · View at Scopus
- J. G. Emery, P. McDonnell, M. B. Burke et al., “Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL,” Journal of Biological Chemistry, vol. 273, no. 23, pp. 14363–14367, 1998. View at Publisher · View at Google Scholar · View at Scopus
- A. Eggert, M. A. Grotzer, T. J. Zuzak et al., “Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced Apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression,” Cancer Research, vol. 61, no. 4, pp. 1314–1319, 2001. View at Scopus
- P. T. Daniel, T. Wieder, I. Sturm, and K. Schulze-Osthoff, “The kiss of death: promises and failures of death receptors and ligands in cancer therapy,” Leukemia, vol. 15, no. 7, pp. 1022–1032, 2001. View at Publisher · View at Google Scholar · View at Scopus
- Q. L. Deveraux and J. C. Reed, “IAP family proteins—suppressors of apoptosis,” Genes & Development, vol. 13, pp. 239–252, 1999. View at Publisher · View at Google Scholar
- I. Tamm, Y. Wang, E. Sausville et al., “IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), bax, caspases, and anticancer drugs,” Cancer Research, vol. 58, no. 23, pp. 5315–5320, 1998. View at Scopus
- S. R. Wiley, K. Schooley, P. J. Smolak et al., “Identification and characterization of a new member of the TNF family that induces apoptosis,” Immunity, vol. 3, no. 6, pp. 673–682, 1995. View at Publisher · View at Google Scholar · View at Scopus
- P. Mirandola, C. Ponti, G. Gobbi et al., “Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity,” Blood, vol. 104, no. 8, pp. 2418–2424, 2004. View at Publisher · View at Google Scholar · View at Scopus
- D. Longman and J. A. Callow, “Specific saccharide residues are involved in the recognition of plant root surfaces by zoospores of Pythium aphanidermatum,” Physiological and Molecular Plant Pathology, vol. 30, no. 1, pp. 139–150, 1987. View at Scopus