Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action
Figure 5
Protective effect of DJS on MPTP-induced dopaminergic neuronal damage in a mouse model of PD. DJS at 50 mg/kg/day for 5 days was administered, and MPTP at 20 mg/kg was injected four times at 2 h interval on the day of last DJS treatment. On the seventh day of MPTP injection, dopaminergic neurons and fibers in the SNpc and the ST, respectively, were stained with a TH antibody. The number of TH-positive cell bodies was counted (a), and the optical density of TH-positive fibers was measured (b). The representative images were shown (c). Scale bar = 100 μm. Each column represents the mean ± SEM from six replications. Data are expressed as percentages relative to the controls. ### significantly different from the control group. ***, * significantly different from the MPTP only treated group.
