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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 984121, 11 pages
http://dx.doi.org/10.1155/2013/984121
Research Article

The Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang Suppresses Th2 Responses and Increases IFNγ in Dermatophagoides pteronyssinus Induced Chronic Asthmatic Mice

1Graduate Institute of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
2Graduate Insitute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan 71101, Taiwan
3School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
4Institute of Medical Science, Tzu Chi University, Hualien 97004, Taiwan
5School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
6Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan
7School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

Received 31 October 2012; Accepted 18 February 2013

Academic Editor: Taixiang Wu

Copyright © 2013 Chia-Hung Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 medicinal plants, has been used in the treatment of asthma. This study demonstrated the immunoregulatory effect of SFYCT on chronic allergic asthma using the Dermatophagoides-pteronyssinus- (Der p-) challenged chronic asthmatic murine model. SFYCT decreased the airway hyperresponseness (AHR), pulmonary inflammatory cell infiltration, and airway remodeling in Der p mice. SFYCT treatment decreased Der p-induced total IgE and Der-p-specific IgG1 but not IgG2a/2b Ab titer in serum of Der p mice. SFYCT also decreased Th2 cytokines, IL-4, IL-5, and IL-13, but increased IFN-γ and IL-12 in the BALF of Der p mice. TGF-β1 and collagen production in the lung of mice were decreased by SFYCT. The mRNA expression of chemokine including Eotaxin, RANTES, and MCP-1 in the lung of Der p mice was decreased by SFYCT. In conclusion, the suppressed Der-p-induced airway inflammation, remodeling, and hyperresponseness in chronic asthma murine model are related to SFYCT inhibits Th2 responses, decreases chemokine expression and promotes IFN-γ and IL-12 production. SFYCT could show Der-p-induced Th2 responses to Th1 responses by increasing IFN-γ which is merit for clinical application on asthma patients.