HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells

<table>Alternative expression of Bcl-2 family proteins including Bcl-XL, Bcl-2, and Bax in fisetin- (FIS-), geldanamycin- (GA-), and radicicol- (RAD-) treated COLO205 cells. COLO205 cells were treated with FIS (60 <i>μ</i>M), GA (2 <i>μ</i>M), RAD (5 <i>μ</i>M), or their combinations for 24 h, and expressions of the indicated proteins were detected by Western blotting using specific antibodies. Data were repeated at least three times, and similar results were obtained. Data related to RAD-inhibited Bcl-2 protein expression from two independent experiments as labeled in 1st and 2nd were involved. The intensity of each band was examined by a densitometric analysis (ImageJ) and expressed as multiples of the control.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells 

Figure 4 | HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells 