Traditional Chinese Medicine Tang-Luo-Ning Ameliorates Sciatic Nerve Injuries in Streptozotocin-Induced Diabetic Rats
Figure 6
Effect of TLN and α-LA on Nrg1/ErbB2 downstream signal pathway in sciatic nerve of streptozotocin-induced rats. A representative western blot ((a), (c), (e), and (g)) and the grey value analyses of protein expression ((b), (d), (f), and (h)) in sciatic nerves from different experimental groups. ((a), (b)) Ratio of P-ErbB2 to T-ErbB2 (P/T); ((c), (d)) ratio of P-Erk to T-Erk (P/T); ((e), (f)) ratio of P-Bad (Ser112) to T-Bad (P/T); ((g), (h)) ratio of P-Akt to T-Akt (P/T). Statistical analysis was performed using the ANOVA procedure test (LSD). Data are expressed as mean ± SD. # versus CTL group, * versus STZ group. per group. The protein expression of ratio of ErbB2 Erk, Bad (P/T) decreased compared with CTL group (), while Tang-Luo-Ning and alpha-lipoic acid intervention could increase the ratio above compared with STZ group (). There were no significant differences of ratio of Akt (P/T) between the four groups. Four groups: CTL group: nonstreptozotocin-induced group, STZ group: streptozotocin-induced diabetic group, TLN group: Tang-Luo-Ning group, and α-LA group: alpha-lipoic acid group. ANOVA: analysis of variance; LSD- test: least significant difference test.
