Investigation of the Lower Resistance Meridian: Speculation on the Pathophysiological Functions of Acupuncture Meridians

Table 1

Comparison of the two migration strategies of single cells [6, 9].

Migration type	Mesenchymal	Amoeboid
Migration strategy	Path generating	Path finding
Mechanism for overcoming tissue barriers	Proteolytic matrix defect	Morphological adaption (constriction ring)
Composition of cell-matrix interactions	Focalized; integrins and MT1-MMP coclustered	Diffuse; integrins nonclustered; MT1-MMP internalized and dissociated from integrins
Migration speed	Very low (formation and turnover of focal contacts are time-consuming; in 3D models it is only 0.1–2 /min)	Very high (for resting and activated leukocytes it may reach 30 /min in vivo)