Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice

Table 8

Acute effect of hexane extract of P. canariensis on fasting blood glucose level of normal and diabetic mice.

Group	Dose (mg/kg)	At the time; of grouping	Blood glucose levels (mg/dL) at different time intervals (hours)
			2 h	4 h	6 h	8 h	12 h
Nondiabetic control	—	102.45±4.56	101.7±5.95	100.56±7.89	102.76±7.42	99.55±8.90	103.15±5.76
Nondiabetic + AL-H	100	103.61±7.92	94.23±6.98^a	84.80±11.04^a	80.75±9.48^a	81.59±8.53^a	94.87±5.69^a
	200	102.48±8.39	89.18±7.42^a	57.29±8.59^a	50.76±6.54^a	54.37±7.90^a	73.43±10.01^a
	400	104.22±6.47	80.38±8.46^a	48.10±4.79^a	41.39±5.25^a	50.49±9.12^a	70.35±6.28^a
SD control	—	375.35±4.87	370.42±5.90	371.28±7.41	378.05±5.16	371.50±8.47	378.14±8.46
MD control	—	246.82±7.53	248.67±8.29	245.78±9.53	248.71±6.37	249.73±8.68	250.04±7.90
SD + AL-H	100	245.62±4.81	225.70±5.80^a	214.52±11.04^a	190.31±7.58^a	200.31±7.58^a	213.31±7.58^a
	200	281.43±3.69	232.61±5.80^a	221.68±8.59^a	182.81±6.85^a	190.02±8.43^a	229.57±9.32^a
	400	274.13±4.23	212.59±5.74^a	198.39±4.81^a	149.67±8.44^a	159.13±7.64^a	180.42±6.27^a
MD + AL-H	100	263.26±6.76	251.38±7.56^a	233.42±10.23^a	221.49±5.46^a	230.16±4.68^a	241.59±6.89^a
	200	249.51±5.64	235.24±4.80^a	219.65±6.49^a	196.08±7.35^a	199.38±6.72^a	240.67±9.47^a
	400	274.38±6.98	258.16±5.39^a	230.47±9.03^a	186.14±7.10^a	191.53±5.37^a	262.54±8.11^a
SD + GB	0.5	348.89±5.79	272.68±6.87^b	201.35±2.59^b	209.43±2.94^b	219.60±1.98^b	266.29±2.83^b

Each of the values represents mean ± SD (𝑛=6). ^a𝑃<0.05 compared to normal group (ANOVA) followed by Dunnett’s test. ^b𝑃<0.05 compared to diabetic group (ANOVA) followed by Dunnett’s test. Glibenclamide (GB).