Neuroprotective Effects of Cuscutae Semen in a Mouse Model of Parkinson’s Disease
Figure 6
MPTP-induced microglial activation is inhibited by CS. Seven days after the final MPTP injection, the animals were sacrificed, and the brains were prepared for immunohistochemistry. CD11b immunostainings in the SN of mice treated with PBS (control), MPTP, and vehicle or MPTP and CS (50, 100, or 200 mg/kg) are shown. The representative images were displayed (a). The scale bars represent 500 μm. The numbers of CD11b-positive cells in the SN were stereologically counted (b). The error bars represent the SEMs. , significantly different from saline with PBS (one-way ANOVA and Student-Newman-Keuls analyses). Dotted lines indicate the SN. The schematic brain sections are from the atlas (Paxinos and Watson, 1986). The square represents SN in the mouse brain. C: control; M: MPTP; CS50: CS50+MPTP; CS100: CS100+MPTP; CS200: CS200+MPTP.
