Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

Figure 3

Effects of MEGR on METH-induced locomotor sensitization in rats. In this study, rats were given either saline or METH once a day for 6 days and then underwent 6 days of withdrawal; during the withdrawal period, either MEGR or DW was administered. The administration of METH over 6 consecutive days induced significant sensitization, which was attenuated by MEGR treatment. All data are expressed as means ± SEM (). MEGR: methanol extract of G. radix, DW: distilled water, S: saline, MEGR60: 60 mg/kg/day MEGR once a day for 6 consecutive days, MEGR180: 180 mg/kg/day MEGR once a day for 6 consecutive days, SCH: a single SCH50911 (3 mg/kg) treatment. versus a single METH group; versus S/DW/METH group; , versus METH/DW/METH group; versus METH/MEGR60/METH group (one-way ANOVA followed by Newman-Keuls post hoc test).