Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

Figure 4

Effects of MEGR on the development of METH-induced CPP in rats. In this study, rats were administered either METH or saline on alternating days for 6 days, and MEGR or DW was given 60 min prior to every METH or saline injection in the nonpreferred chamber. METH treatment for 3 nonconsecutive days elicited CPP for the METH-paired chamber, which was blocked by pretreatment with MEGR. All data are expressed as means ± SEM (). MEGR: methanol extract of G. radix, DW: distilled water, S: saline, MEGR180: 180 mg/kg/day MEGR. versus S/DW/S group; versus S/DW/METH group (one-way ANOVA followed by Newman-Keuls post hoc test).