Evidence-Based Complementary and Alternative Medicine

Research Article

Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation

Table 2

Results obtained for the plant extracts in the bioassays (test concentration 100 g/mL) of the screening platform. Results are given as either (+) for activation/stimulation or (−) for no activation/stimulation. For C. elegans (+) means reduction of fat accumulation (acc.). Extracts not tested are indicated by (nt), cytotoxic effects are indicated by (†), and glucose uptake is indicated as (GU).
Plant speciesExtractPPARγ transactivationAdipocyte differentiationGU in adipocytesGU in myotubesFat acc. in C. elegans
BroccoliDCM+†nt−+
MeOH−ntnt+−
KaleDCM−ntnt−+
MeOH−ntnt−+
CarrotDCM+−+++
MeOH−ntnt−−
Golden root aDCM+−+++
aMeOH−ntnt−+
bDCM−−+++
bMeOH−ntnt−+
ElderDCM+−+++
MeOH−ntnt++
SavoryDCM+−+−+
MeOH−ntnt+−
ThymeDCM+−+++
MeOH+−nt++
Aerial parts; broots.