Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain

<table>Effects of EA on the CCI-induced thermal hyperalgesia. Thermal hyperalgesia was measured before surgery, day 3, day 7, day 14, and day 21 after the CCI surgery, respectively. Compared with the normal rats, the ipsilateral PWL of CCI rats was significantly decreased from day 3 and sustained to day 21 after the CCI surgery (<svg height="11.375" id="M25" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). EA treatments were applied to rats every other day from day 7 to day 21. Neither chronic EA nor sham EA at GV20–GB34 had effect on the ipsilateral PWL of CCI rats (<svg height="11.375" id="M26" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus normal rats).</table>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain 