Review Article
Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine
Table 1
Herbs with clearing away heat and toxic material functions with strong FASN inhibitory effect. In TCM theory, noxious heat is one of the underlying pathologies of the occurrence and development of malignancy. Therefore, herbal medicine with detoxification effect plays an indispensable role in cancer prevention and treatment. With pharmacological studies and analysis of their chemical composition, the herbs anticancer mechanism mainly includes direct inhibition of tumor-induced apoptosis of tumor cells, regulation of immune function, anti-inflammatory, detoxification, fever, blocking, and anticarcinogenic mutations. These kinds of herbs are widely used in the clinical treatment of cancer.
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