Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine

Table 2

Herbs with promoting blood circulation for removing blood stasis functions with strong FASN inhibitory effect. Stagnation of Qi and poor blood circulation are recognized as the main pathologies of certain groups of malignancy. This group of herbal medications may not only induce apoptosis but also improve the antitumor mechanism of a body's blood circulation, which improves the local hypoxic state, as well as regulating and promoting immunity.

活 血化 瘀 Promoting blood circulation for removing blood stasis	Chemical component	Pharmacological action
The fruit of Crataegus pinnatifida Bunge; (山 楂)	Crataegolic acid; Chlorogenic acid; Epicatechin; Epicatechol; Flavonoids	Blocking synthesis of nitrosamine
Rosa chinensis Jacq.; (月 季花)	Gallic acid	Antibreast cancer; antithyroid neoplasm
Paeonia veitchii Lynch; (赤 芍)	Paeoniflorin; Galloylpaeoniflorin; Paeonol; Lacioflorin; Catechin	Antitumor
Paeonia suffruticosa Andr.; (牡 丹皮)	Paeonol; Paeonoside; Paeonolide; Paeoniflorin; Gallic acid; Phytosterol; Alkaloid	Antitumor; immunoregulation; bacteriostat
Spatholobus suberectus Dunn; (雞 血藤)	Daidzein; Epicatechin; Protocatechuic acid; Brassicasterol; Stigmasterol; β-sitosterol; Auriculatin	Antitumor; bacteriostat
Polygonum cuspidatum Sieb. etc Zucc; (虎 杖)	Polydatin; Emodin; Physcion; Chrysophanol; Citreorsein; Anthraglycside; Resveratrol	Antitumor; immunoregulation; antibiosis; antivirus; elevation of white blood cell counts
Herba lycopi; (澤 蘭)	Essential oils; Flavonoid Glycosides; Saponins; Phenols; Tannins	Antitumor, immunoregulation