Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine

Table 5

Herbs with reducing phlegm and dehumidification functions with strong FASN inhibitory effect. Phlegm in the body can be not only the pathological product of the body but also a risk factor for tumor development. This group of herbs can relieve symptoms caused by the tumor and have antitumor effects.

化 痰去 濕 Reduce phlegm and dehumidification	Chemical components	Pharmacological action
Uncaria gambier Roxb. (兒 茶)	Catechu-tannic acid; Catechin; Epicatechin; Phlobatannin; Quercetin; Kaempferol; Afzelechin; Aflatoxin	Inhibition of cancer cell growth; elevation of white blood cells
Pyrrosia lingua (Thunb) Farw. (石 葦)	Diploptene; saponins; Anthraquinone; Flavonoids;	Antitumor; hematischesis; diuresis
Gleditsia sinensis Lam. (皂 角刺)	Flavonoids; Phenol; Fustin; Fisetin	Antitumor
Eriobotrya japonica (Thunb.) Lindl. (枇 杷葉)	Nitrilosides; Farnesol; Amygdalin; Citric acid; Oleanolic Acid; Eugeniin; Tannins	Antitumor; reduce phlegm;
Morus alba L. (桑 白皮)	Flavonoids; Mulberrin; Morusin; Palmitic acid; Essential oils	Inhibition of the growth of tumor; diuresis; detumescence