Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine

Table 7

TCM prescriptions with potential FASN inhibitory effect. Among these six commonly used antitumor prescriptions, all of them contain herbs with FASN inhibitory effect. Although studies have shown the antitumor effect of these prescriptions, a lack of studies have been carried out investigating their pharmacological actions and the underlying mechanisms.

Number	Name of the Prescription	Composition	Effect
1	Chaihu Shugan Powder; (柴 胡疏 肝散)	Pericarpium Citri reticulatae (陳 皮); Root of Chinese thorowax (柴 胡); Rhizoma Ligustici (川 芎); Fructus Aurantii (枳 殼); The root of Paeonia lactiflora  Pall. (芍 藥); Radix glycyrrhizae Preparata (炙 甘草); Rhizoma cyperi (香 附)	1. Smoothing Liver and Regulating Qi; 2. Invigorating Blood Circulation and Alleviate Pain
2	Taoren Chengqi Decoction; (桃 核承 氣湯)	Semen persicae (桃 仁); Radix glycyrrhiza (甘 草); Mirabilite (芒 硝); Rhuen palmatum  L. (大 黃); Ramulus Cinnamomi (桂 枝)	Promoting Blood Circulation for Removing Blood Stasis
3	Fuyuan Huoxue Decoction; (復 元活 血湯)	Root of Chinese Thorowax (柴 胡); Radix Trichosanthis (瓜 蔞根); Chinese angelica (當 歸); Flos carthami (紅 花); Radix Glycyrrhizae (甘 草); Squama manis (穿 山甲); Rhuen palmatum  L. (大 黄); Semen Persicae (桃 仁)	Promoting Blood Circulation for Removing Blood Stasis
4	Xuefu Zhuyu Decoction; (血 府逐 瘀湯)	Chinese angelica (當 歸); Rehmannia glutinosa Libosch (生 地); Semen persicae (桃 仁); Flos carthami (紅 花); Fructus Aurantii (枳 殼); Paeonia vaitchii  Lynch (赤 芍); Root of Chinese thorowax (柴 胡); Radix glycyrrhizae (甘 草); Platycodon grandiforus (桔 梗); Rhizoma ligustici Chuanxiong (川 芎); Radix Achyranthis bidentatae (牛 膝)	1. Promoting Blood Circulation for Removing; Blood Stasis; 2. Promoting the Qi Circulation and Stopping Pain
5	Wenjing Decoction; (溫 經湯)	Tetradium ruticarpum (吳 茱萸); Chinese angelica (當 歸); Rhizoma Ligustici Chuanxiong (川 芎) The root of Paeonia lactiflora  Pall. (芍 藥); Panax ginseng C. A. Mey. (人 參); Ramulus Cinnamomi (桂 枝); Colla Corii Asini (阿 膠) Paeonia suffruticosa  Andr. (牡 丹皮); Zingiber officinale (生 薑); Radix glycyrrhizae (甘 草); Pinellia ternata (半 夏); Radix ophiopogonis (麥 門冬)	1. Promoting Blood Circulation for Removing Blood Stasis; 2. Warming Channel for Dispelling Cold
6	Xiaoyao Powder; (逍 遙散)	Root of Chinese thorowax (柴 胡); Chinese angelica (當 歸); The root of Paeonia lactiflora  Pall. (白 芍); Atractylodes macrocephala (白 術); Wolfiporia cocos (茯 苓); Rhizoma Zingiberis Recens (生 薑); Mentha haplocalyx (薄 荷); Radix glycyrrhizae Preparat (炙 甘草)	1. Smoothing Liver and Regulating Qi; 2. Promoting Blood Circulation for Removing Blood Stasis

In Composition, Herbal Medicines with the screening of FASN inhibitory effect are bolded.