Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers

Table 2

Maximum concentration (𝐶_max) and area under the plasma concentration-time curve (AUC) of plasma glucose after breakfast and dinner on 19 healthy volunteers (mean ± SEM).

	Dose (mg/d, p.o.)	𝐶max of plasma glucose (mmol/L) after breakfast
		𝑛	First day	Second day	Change
Acarbose	50	19	6.93±0.84	6.64±0.86	−0.29±0.74
TZQ- 2 tables	1280	19	6.75±0.74	6.90±1.06	0.15±0.95
TZQ- 3 tables	1920	19	6.83±1.03	6.92±0.73	0.10±0.84
TZQ- 4 tables	2560	19	6.78±0.99	7.17±0.92	0.39±0.82
Placebo	—	19	6.97±1.14	7.23±0.95	0.27±0.84
	Dose (mg/d, p.o.)	𝐶max of plasma glucose (mmol/L) after dinner
		𝑛	First day	Second day	Change^#
Acarbose	50	19	7.28±1.03	6.54±0.89^∗	−0.75±0.88
TZQ- 2 tables	1280	19	7.38±0.84	7.14±1.38	−0.24±1.40
TZQ- 3 tables	1920	19	7.69±0.91	7.00±1.08^∗	−0.69±0.90
TZQ- 4 tables	2560	19	7.35±0.97	6.72±0.77^∗	−0.63±1.09
Placebo	—	19	7.06±0.86	7.60±1.53	0.55±1.32
	Dose (mg/d, p.o.)	AUC of Plasma glucose (mmol·h/L) after breakfast
		𝑛	First day	Second day	Change
Acarbose	50	19	16.29±2.01	16.38±1.79	0.09±1.45
TZQ- 2 tables	1280	19	16.60±1.43	16.31±1.54	−0.28±1.19
TZQ- 3 tables	1920	19	16.65±1.91	16.34±1.08	−0.31±1.50
TZQ- 4 tables	2560	19	16.79±2.01	16.69±1.77	−0.09±1.44
Placebo	—	19	16.55±1.69	16.39±1.83	−0.16±1.04
	Dose (mg/d, p.o.)	AUC of plasma glucose (mmol·h/L) after dinner
		𝑛	First day	Second day	Change
Acarbose	50	19	17.59±1.99	17.06±2.03	−0.52±1.78
TZQ- 2 tables	1280	19	18.01±0.41	17.23±3.32	−0.78±3.43
TZQ- 3 tables	1920	19	18.08±1.87	17.25±2.91	−0.82±2.24
TZQ- 4 tables	2560	19	17.98±1.63	17.10±2.16	−0.87±2.27
Placebo	—	19	17.29±1.60	17.32±2.84	0.03±2.79

^∗𝑃<0.05 versus first day (before treatment). ^#𝑃<0.05 five treatments compared using ANOVA.