Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers

Table 3

Maximum concentration (𝐶_max) and area under the plasma concentration-time curve (AUC) of plasma IRI after breakfast and dinner on 19 healthy volunteers (mean ± SEM).

	Dose (mg/d, p.o.)	𝐶max of plasma IRI (mIU/L) after breakfast
		𝑛	First day	Second day	Change^#
Acarbose	50	19	75.77±50.30	64.10±35.92	−11.67±32.69
TZQ- 2 tables	1280	19	80.02±51.86	86.83±49.25	7.28±29.33
TZQ- 3 tables	1920	19	85.65±49.82	90.83±44.86	5.18±24.35
TZQ- 4 tables	2560	19	77.42±40.10	96.85±49.99^∗	19.43±31.44
Placebo	—	19	85.36±46.86	101.32±54.16	15.96±39.25
	Dose (mg/d, p.o.)	𝐶max of plasma IRI (mIU/L) after dinner
		𝑛	First day	Second day	Change^#
Acarbose	50	19	54.85±37.42	44.00±30.64	−10.85±35.69
TZQ- 2 tables	1280	19	42.78±24.93	56.50±29.19	13.72±23.77
TZQ- 3 tables	1920	19	55.79±29.29	48.25±27.37	−7.27±30.70
TZQ- 4 tables	2560	19	48.86±30.92	51.99±28.55	3.13±20.49
Placebo	—	19	52.43±26.17	65.09±3.62	12.66±36.66
	Dose (mg/d, p.o.)	AUC of plasma IRI (mIU/h/L) after breakfast
		𝑛	First day	Second day	Change
Acarbose	50	19	107.73±70.16	103.45±50.89	−4.28±39.61
TZQ- 2 tables	1280	19	113.90±61.00	129.24±60.36	15.34±37.52
TZQ- 3 tables	1920	19	127.50±70.60	130.74±61.47	3.24±43.54
TZQ- 4 tables	2560	19	122.72±71.76	141.48±68.06	18.76±39.57
Placebo	—	19	128.43±79.93	137.97±63.00	9.54±47.88
	Dose (mg/d, p.o.)	AUC of plasma IRI (mIU/h/L) after dinner
		𝑛	First day	Second day	Change
Acarbose	50	19	66.01±35.68	74.75±43.69	8.73±39.39
TZQ- 2 tables	1280	19	66.45±31.29	92.68±36.51	26.23±28.88
TZQ- 3 tables	1920	19	84.95±49.02	85.23±43.16	0.28±47.98
TZQ- 4 tables	2560	19	77.84±45.67	94.32±47.68	16.48±35.71
Placebo	—	19	68.39±29.40	96.21±7.93	27.82±26.31

^∗𝑃<0.05 versus first day (before treatment). ^#𝑃<0.05 five treatments compared using ANOVA.