Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers

Table 4

Maximum concentration (𝐶_max) and area under the plasma concentration-time curve (AUC) of plasma C-peptide after breakfast and dinner on 19 healthy volunteers (mean ± SEM).

	Dose (mg/d, p.o.)	𝐶max of plasma C-peptide (ng/mL) after breakfast
		𝑛	First day	Second day	Change^#
Acarbose	50	19	5.13±2.20	4.63±1.29^∗	−0.50±1.19
TZQ- 2 tables	1280	19	4.68±1.71	5.46±1.98^∗	0.77±1.09
TZQ- 3 tables	1920	19	5.20±2.33	5.57±2.11	0.37±1.69
TZQ- 4 tables	2560	19	5.08±2.17	5.41±2.04	0.33±1.11
Placebo	—	19	5.09±2.11	5.54±2.29^∗	0.45±1.46
	Dose (mg/d, p.o.)	𝐶max of plasma C-peptide (ng/mL) after dinner
		𝑛	First day	Second day	Change^#
Acarbose	50	19	4.56±1.49	4.35±1.80	−0.21±1.20
TZQ- 2 tables	1280	19	4.31±1.17	5.20±1.56^∗	0.89±0.76
TZQ- 3 tables	1920	19	4.98±1.58	4.64±1.50	−0.33±1.00
TZQ- 4 tables	2560	19	4.50±1.80	4.61±1.45	0.11±1.17
Placebo	—	19	4.70±1.49	5.13±1.57	0.43±1.15
	Dose (mg/d, p.o.)	AUC of plasma C-peptide (ng/h/mL) after breakfast
		𝑛	First day	Second day	Change^#
Acarbose	50	19	9.83±3.40	9.76±2.92	−0.08±1.23
TZQ- 2 tables	1280	19	9.67±3.04	11.40±3.74^∗	1.73±1.72
TZQ- 3 tables	1920	19	10.26±4.26	11.39±3.90	1.12±2.45
TZQ- 4 tables	2560	19	10.32±4.37	11.45±4.33^∗	1.13±2.07
Placebo	—	19	10.40±4.16	11.22±4.22	0.81±1.78
	Dose (mg/d, p.o.)	AUC of plasma C-peptide (ng/h/mL) after dinner
		𝑛	First day	Second day	Change^#
Acarbose	50	19	9.29±2.32	9.23±2.90	−0.07±1.73
TZQ- 2 tables	1280	19	9.92±2.41	11.62±3.08^∗	1.70±1.42
TZQ- 3 tables	1920	19	10.66±3.65	10.64±3.41	−0.02±2.06
TZQ- 4 tables	2560	19	9.74±2.96	10.91±3.53^∗	1.17±1.94
Placebo	—	19	10.30±3.14	11.28±2.82	0.98±2.08

^∗𝑃<0.05 versus first day (before treatment). ^#𝑃<0.05 five treatments compared using ANOVA.