Bench to Bed Evidences for Pharmacokinetic and Pharmacodynamic Interactions Involving Oseltamivir and Chinese Medicine

Figure 4

Comparison of inhibitory effect on virus replication of H3N2 of ex vivo plasma samples of (a) Rat treatment groups (𝑛=10∼12 in each group) with all six treatment groups significantly different from control group (***𝑃<0.01), and (b) Human studies groups 1A and 1B collected at 2 h after drug administration on Day 5 (*𝑃<0.05; **𝑃<0.01; ***𝑃<0.001).

(a)

(b)