Bench to Bed Evidences for Pharmacokinetic and Pharmacodynamic Interactions Involving Oseltamivir and Chinese Medicine

Table 4

Summary of geometric mean, geometric mean ratio, and 90% confidence internal (90% CI) of pharmacokinetic parameters between WM and WM + CMF1.

Analyte	Parameters	Geometric mean		GM Ratio, %^b	90% CI, %^c
		WM; (𝑛=14)	WM + CMF1; (𝑛=14)
OA	𝐶max (ng/mL)	62.42	48.81	78.19	60.82–100.51
	AUC0--12h (ng·h/mL)	129.86	124.76	96.08	88.48–104.33
	12 h Cum. amt. (𝜇g)^a	2745.53	2726.98	99.32	85.56–115.30
OC	𝐶max (ng/mL)	526.27	480.59	91.32	84.81–98.33
	AUC0--12h (ng·h/mL)	4453.91	4067.40	91.32	83.80–99.52
	12 h Cum. amt. (𝜇g)^a	71215.61	61224.10	85.97	76.64–96.44
OC/OA	AUC0--12h ratio	34.30	32.60	95.05	85.64–105.50
	12 h Cum. amt. ratio	25.94	22.45	86.56	76.49–97.94

a12 h cumulative amount of analyte in urine.
^bGeometric mean ratio of (WM + CMF1)/WM.
^c90% CI criteria of 80%–125% [10].