KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells

Figure 2

The effects of KCHO-1 on COX-2 and iNOS (a) expression and PGE₂ (b) and NO (c) production in LPS-stimulated BV2 microglia. The cells were pretreated for 12 h with the indicated concentrations of KCHO-1 and stimulated for 18 h with LPS (1 μg/mL). Western blot analyses (a) were performed as described in the Materials and Methods, and representative blots from 3 independent experiments are shown. The concentration of PGE₂ (b) and NO (c) was determined as described. The data represent the mean values from 3 experiments ± SD. compared with the LPS-treated group.

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