Lipid Lowering Effect of Punica granatum L. Peel in High Lipid Diet Fed Male Rats
Table 1
Effect of i.p. administration of hydroethanolic extract of Punica granatum peel at doses 50, 100, 200, and 300 mg/kg on liver and kidney coefficients, serum parameters, and histopathological damage of liver in high lipid diet fed rats.
Parameters
Control
Saline
Extract (mg/kg)
50
100
200
300
Liver coefficient
0.028
0.042
0.037
0.035
0.039
0.039
Kidney coefficient
0.0027
0.0036
0.0033
0.0033+
0.0035
0.0036
Triglycerides (mg/dL)
146 ± 21
475 ± 11***
381 ± 23
325 ± 43
302 ± 31
210 ± 27+++
Cholesterol (mg/dL)
73 ± 8
110 ± 11***
87 ± 9++
82 ± 5++
80 ± 9++
81 ± 7++
LDL (mg/dL)
92 ± 6
321 ± 11**
209 ± 23
145 ± 29+
79 ± 8++
61 ± 7+++
HDL (mg/dL)
98 ± 9
28 ± 3*
89 ± 11
128 ± 5+++
179 ± 18+++
185 ± 20+++
AST (UI/L)
1234 ± 34
1538 ± 47***
1219 ± 39+++
1232 ± 71+++
1170 ± 49+++
1233 ± 36+++
ALT (UI/L)
1267 ± 56
1553 ± 32***
1130 ± 44+++
1246 ± 51+++
1233 ± 68+++
1290 ± 54+++
AP (UI/L)
983 ± 21
1362 ± 71***
1311 ± 39
1248 ± 48
1100 ± 59++
1049 ± 78+++
Histopathological damage of liver
0 ± 0
1.5 ± 0.11*
0.5 ± 0.23
0.4 ± 0.23
0.17 ± 0.31+
0.09 ± 0.27+
, , different from control group. , , different from saline group.
