Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from <i>Syzygium campanulatum</i> Korth

<div>(a) The inhibitory effects of DMC and ethanolic extract of<i> S. campanulatum</i> on the migration property of HT-29 cells, which is a characteristic of metastasis of the cancer cells. (b) Clonogenic cell survival (%) of HT-29 treated with 1% DMSO as a negative control, 3 <svg height="9.7821pt" id="M59" style="vertical-align:-3.57194pt" version="1.1" viewbox="-0.0498162 -6.21016 7.64704 9.7821" width="7.64704pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M538 96L524 119C492 88 454 63 446 63C439 63 434 70 440 101C463 223 491 341 518 448H508L433 422L401 276C355 192 240 56 188 56C163 56 154 89 163 133C184 233 207 338 235 443L230 448L152 424L58 17C40 -60 23 -143 23 -185C23 -241 42 -261 63 -261C92 -261 117 -241 125 -227L124 -221C109 -209 89 -165 89 -103C89 -55 96 -13 105 26H107C121 -3 134 -12 151 -12C172 -12 194 -5 221 16C279 61 330 124 384 194H386C381 159 377 141 368 105C343 3 363 -12 383 -12C416 -12 486 35 538 96Z" id="g113-234"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="555" vert-adv-y="555"></glyph.data></g></svg>g/mL of 5-fluorouracil as positive control, and indicated concentrations of<i> S. campanulatum</i> ethanolic extract and DMC. (c) The percentage of surviving fraction obtained after the treatment with DMC and ethanolic extract of<i> S. campanulatum</i>. The percentage of surviving fraction of the HT-29 colonies was decreased with increasing concentration of DMC and ethanolic extract<i> S. campanulatum</i>, mean ± SD (<svg height="6.42315pt" id="M60" style="vertical-align:-0.2129903pt" version="1.1" viewbox="-0.0498162 -6.21016 18.6939 6.42315" width="18.6939pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,10.586,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g></svg> either 6 or 10).</div>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from <i>Syzygium campanulatum</i> Korth 

Figure 5 | Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth 