Antidiabetic and Antioxidative Effect of Jiang Tang Xiao Ke Granule in High-Fat Diet and Low-Dose Streptozotocin Induced Diabetic Rats

Table 1

Effect of JTXK granule on glucose levels in DM rats.

Groups	Dose (g/kg)	FBG (mmol/L)		RBG (mmol/L)
		Before treatment	After treatment	Before treatment	After treatment
Normal	—	6.0±0.31	5.43±0.29	7.04±0.20	6.79±0.21
DM	—	30.6±0.91^∗∗	27.82±0.46^∗∗	30.88±1.09^∗∗	30.56±1.04^∗∗
DM/pioglitazone	0.0015	29.68±0.96	23.94±0.79^#	29.93±1.26	25.24±2.09^#
DM/JTXK	9	29.19±1.02	24.51±0.80^#	30.05±1.37	25.62±1.42^#

Diabetes mellitus (DM) rats were induced by combination of high-fat diet and streptozotocin described in Section 2. Jiang Tang Xiao Ke (JTXK) granule 9 g/kg (based on crude herbal material) and pioglitazone dissolved in distilled water were orally administrated to DM rats for 4 consecutive weeks. Normal and drug-untreated DM rats were treated with the vehicle. After that, fasting blood glucose (FBG) and random blood glucose (RBG) levels were measured using a glucometer. Values are expressed by means ± SE, with 𝑛=10. **𝑃<0.01 versus normal rats; ^#𝑃<0.05 versus DM rats. Statistically significant differences were determined using a one-way ANOVA followed by Dunnett’s post hoc analysis.