Antidiabetic and Antioxidative Effect of Jiang Tang Xiao Ke Granule in High-Fat Diet and Low-Dose Streptozotocin Induced Diabetic Rats

Table 4

Effect of JTXK granule on oxidative stress and hepatic function in DM rats.

Groups	Dose (g/kg)	Serum NO; (umol/L)	Serum SOD; (U/mL)	Serum MDA; (mmol/L)	Serum ALT activity; (U/L)
Normal	—	22.43±2.83	53.43±8.41	5.21±0.35	60.00±1.93
DM	—	49.10±6.51^∗	18.71±6.64^∗	8.12±1.30^∗∗	157.89±26.75^∗∗
DM/pioglitazone	0.0015	40.78±4.24	33.83±8.30^#	5.56±0.61^##	85.90±8.79^##
DM/JTXK	9	23.43±3.89^##	29.97±3.66^#	5.38±0.68^##	79.50±10.04^##

Experimental details were described in Table 1. Four weeks after drug treatment serum nitric oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA), and alanine aminotransferase (ALT) were determined. Values are expressed by means ± SE, with 𝑛=10. *𝑃<0.05 and **𝑃<0.01 versus normal rats; ^#𝑃<0.05 and ^##𝑃<0.01 versus DM rats. Statistically significant differences were determined using a one-way ANOVA followed by Dunnett’s post hoc analysis.