Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia

Table 2

Comparison of parameters in each group.

	Prostate weight (g)	Oxidative stress		Apoptosis	Activity of 5-alpha reductase
		Activity of SOD in serum (%)	Concentration of 8-OHdG in prostate (ng/mL)	Concentration of caspase-3 in prostate (ug/mL)	In serum (%)	In prostate (%)
Control	1.040±0.061	35.761±2.115	0.620±0.061	3.661±0.053	5.668±0.292	7.178±0.092
BPH	1.421±0.039^∗	81.345±0.892^∗	7.651±0.306^∗	24.456±1.625^∗	18.863±0.648^∗	27.176±0.719^∗
BPH + SE1	0.988±0.040^∗∗	62.047±0.875^∗∗	6.493±0.253^∗∗	17.212±0.787^∗∗	11.515±0.344^∗∗	18.177±0.643^∗∗
BPH + SE2	0.878±0.068^∗∗	55.816±1.488^∗∗	4.060±0.355^∗∗	12.975±0.703^∗∗	11.347±0.120^∗∗	15.453±0.382^∗∗

The mean prostate weight of the BPH group was significantly higher than that of the control group, whereas the means of the BPH + SE groups were significantly reduced compared to the BPH group.
A significant increase in oxidative stress was found in the BPH group compared with the control group, and oxidative stress was significantly reduced in the two BPH + SE groups.
A significant increase in the concentration of caspase-3 was found in the BPH group compared with the control group, and it was significantly decreased in the two BPH + SE groups.
A significant increase in 5-alpha reductase activity was found in the BPH group compared with the control group, and it was significantly reduced in the two BPH + SE groups.
BPH: benign prostatic hyperplasia group; BPH + SE1: BPH group treated with Seoritae extract (228 mg/kg); BPH + SE2: BPH group treated with Seoritae extract (457 mg/kg); SOD: superoxide dismutase; 8-OHdG: 8-hydroxy-2-deoxyguanosine.
∗Significant difference (𝑃<0.05) compared with the control group.
∗∗Significant difference (𝑃<0.05) compared with the BPH group.