In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell

Figure 8

Representative histological images of tumor masses, taken from tumor-bearing control (a), gemcitabine (b), platycodin D 200 (c), 100 (d) and 50 (e) mg/kg treated mice. Gemcitabine was intraperitoneally administered at 160 mg/kg, 7-day intervals; Platycodin D was orally administered, once a day; HE = hematoxylin-eosin stain; PARP = cleaved poly(ADP-ribose) polymerase; COX-2 = cyclooxygenase-2; iNOS = inducible nitric oxide synthases; TNF = tumor necrosis factor; Scale bars = 167 μm.

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