In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell

Table 2

Tumor mass and organ weights in H520 tumor cell xenograft mice.

Organs	Groups
	Intact control	TB control	Gemcitabine	Platycodin D
				200 mg/kg	100 mg/kg	50 mg/kg
Absolute weight (g)
Tumor mass		6.887 ± 0.991	3.674 ± 0.450^c	2.105 ± 0.366^c	3.559 ± 0.679^c	4.235 ± 0.528^c
Spleen	0.104 ± 0.020	0.040 ± 0.005^d	0.034 ± 0.009^df	0.071 ± 0.009^de	0.059 ± 0.007^de	0.051 ± 0.008^de
Submandibular lymph node	0.013 ± 0.002	0.002 ± 0.001^a	0.002 ± 0.001^a	0.010 ± 0.002^ac	0.007 ± 0.001^ac	0.005 ± 0.001^ac
Periovarian fat pad	0.167 ± 0.050	0.017 ± 0.007^d	0.009 ± 0.002^de	0.074 ± 0.021^de	0.059 ± 0.010^de	0.049 ± 0.013^de
Relative weights (% of body weight)
Tumor mass		37.486 ± 7.219	23.167 ± 4.119^e	10.065 ± 1.519^e	17.643 ± 3.356^e	23.103 ± 2.919^e
Spleen	0.449 ± 0.110	0.216 ± 0.029^d	0.216 ± 0.067^d	0.340 ± 0.052^e	0.294 ± 0.047^de	0.277 ± 0.049^df
Submandibular lymph node	0.054 ± 0.008	0.012 ± 0.005^a	0.012 ± 0.007^a	0.046 ± 0.007^bc	0.035 ± 0.006^ac	0.027 ± 0.007^ac
Periovarian fat pad	0.725 ± 0.249	0.091 ± 0.033^d	0.057 ± 0.012^df	0.353 ± 0.100^de	0.295 ± 0.052^de	0.264 ± 0.065^de

Values are expressed mean ± S.D. of eight mice.
TB: tumor bearing.
Gemcitabine was intraperitoneally administered at 160 mg/kg, 7-day intervals.
Platycodin D was orally administered, once a day.
^a and ^b as compared with intact control by LSD test.
^c as compared with TB control by LSD test.
^d as compared with intact control by MW test.
^e and ^f as compared with TB control by MW test.