In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell

Table 3

Changes on the splenic cytokine contents in H520 tumor cell xenograft mice.

Groups	Tumor necrosis factor-	Interleukin-1	Interleukin-10
Controls
Intact	98.63 ± 10.54	33.69 ± 5.72	88.98 ± 18.71
TB	42.22 ± 10.76^a	9.45 ± 2.22^d	37.19 ± 7.35^a
Reference
Gemcitabine	29.47 ± 10.28^ac	6.86 ± 1.49^df	27.61 ± 7.10^a
Platycodin D
200 mg/kg	72.17 ± 10.23^ac	21.52 ± 5.77^de	69.70 ± 11.58^ab
100 mg/kg	82.95 ± 6.13^ac	17.25 ± 2.31^de	58.32 ± 11.10^ab
50 mg/kg	57.50 ± 7.92^ac	12.32 ± 2.19^de	50.72 ± 12.56^ac

Values are expressed mean ± S.D. of eight mice, pg/mg protein.
TB: tumor-bearing.
Gemcitabine was intraperitoneally administered at 160 mg/kg, 7-day intervals.
Platycodin D was orally administered, once a day.
^a as compared with intact control by LSD test.
^b and ^c as compared with TB control by LSD test.
^d as compared with intact control by MW test.
^e and ^f as compared with TB control by MW test.