Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3β-CREB Signaling Pathway

Figure 6

Hippocampal GSK-3β, p-GSK-3β, CREB, p-CREB, BDNF, and NF-L protein levels in the corticosterone-induced mouse depression model were determined by Western blot analysis. The values of GSK-3β (a), CREB (c), BDNF (e), and NF-L (f) levels were normalized against the amount of β-actin, while the values of p-GSK-3β (Ser9) (b) and p-CREB (Ser133) (d) were normalized against the amount of GSK-3β and CREB, respectively. **𝑃<0.01 versus the CORT group, *𝑃<0.05 versus the CORT group, and ^##𝑃<0.01 versus the control group.

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