Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
Figure 4
The mRNA expression of Col2α1, Col10α1, MMP3, and MMP13. (a) In the operated rats, the mRNA expression of Col2α1 decreases significantly at all time points but upregulated significantly after pretreatment with ligustrazine, while meloxicam has no effect on Col2α1 expression. (b)-(c) MMP3 and MMP13 mRNA expression increased significantly at all time points in model groups, but ligustrazine and meloxicam treatment decreased gene expression. (d) Col10α1 mRNA expression increased significantly at all time points in model groups and ligustrazine treatment decreased gene expression significantly at all time points, while meloxicam has no deducing role on its expression. The columns represent the mean ± SD of three independent experiments. compared to model group in the same month.
