Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System

Figure 3

JTT protected against MPTP-induced reductions in TH expression in the mouse SN. C57BL/6 mice were treated with JTT for 7 days and then MPTP (20 mg/kg, 4 times, at 2-hour interval, i.p.) was injected on the 8th day. Mice were sacrificed on the 7th day after MPTP injection (15th day of the experiment period) and after behavioral tests. Photomicrographs of representative SN (a) sections stained with an antibody against TH. Reduced activity of TH-neurons was observed in MPTP treated mice, which was partially prevented by treatment with JTT. The number of TH-positive neurons in the SN (b) was expressed as the mean ± S.D, 𝑛=5. *𝑃<0.05, **𝑃<0.01 versus vehicle group, ^##𝑃<0.01 versus JTT-H.

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