In Vitro and In Vivo Characterization of the New Analgesic Combination Beta-Caryophyllene and Docosahexaenoic Acid

Figure 10

Failure of timely resolution of inflammation drives chronic inflammatory conditions and pain. Resolution of inflammation requires the elimination of key inflammatory cells and the downregulation of proinflammatory mediators at the inflamed sites. Docosahexaenoic acid (DHA) is converted into resolvins and protectins that counteract excessive inflammatory responses and stimulate proresolving mechanisms, tissue repair, and decreased pain. Beta-caryophyllene (BCP) reduces inflammation by its action on CB2 receptors, which are mostly expressed on immune cells and microglia.