In Vitro and In Vivo Characterization of the New Analgesic Combination Beta-Caryophyllene and Docosahexaenoic Acid

Figure 8

Flexing (a), licking (b), and jerking (c) of the injected paw in OIL (white), BCP (light gray), and BCP+DHA (dark gray) groups during the second phase (20–45 min, a–c) of FT1, FT2, and FT3. ANOVA showed that BCP and BCP+DHA administration significantly reduced the formalin-induced responses, in particular, during the second phase of FT2 and FT3. Values are means ± SEM. ^∗∗𝑃<0.0001 versus FT1; ^∗𝑃<0.02 versus FT1; ^##𝑃<0.0001 versus OIL, same test; ^#𝑃<0.01 versus OIL, same test.

(a)

(b)

(c)